GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs932541 | 1 | rs6111151 | chr20:16456032 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.67 | 0.000274 | Intelligence |
| THCA | cis | rs932541 | 1 | rs6111152 | chr20:16456088 | KIF16B | chr20:16252749-16554078:- | -0.17 | -3.75 | 0.000196 | Intelligence |
| THCA | cis | rs932541 | 1 | rs6111153 | chr20:16456113 | KIF16B | chr20:16252749-16554078:- | -0.17 | -3.77 | 0.000185 | Intelligence |
| THCA | cis | rs932541 | 1 | rs6111154 | chr20:16456201 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.77 | 0.000186 | Intelligence |
| THCA | cis | rs932541 | 1 | rs6111155 | chr20:16456461 | KIF16B | chr20:16252749-16554078:- | -0.16 | -3.73 | 0.000213 | Intelligence |
| THCA | cis | rs61142792 | 1 | rs61142792 | chr5:176983463 | DOK3 | chr5:176928915-176937427:- | 0.27 | 6.07 | 2.67E-9 | Alzheimer disease and age of onset |
| THCA | cis | rs7267979 | 1 | rs6115140 | chr20:25285507 | ENTPD6 | chr20:25176339-25207360:+ | -0.31 | -7.15 | 3.38E-12 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115140 | chr20:25285507 | FAM182A | chr20:26035250-26067552:+ | -0.19 | -3.45 | 0.000609 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115140 | chr20:25285507 | FAM182B | chr20:25744102-25848786:- | 0.25 | 5.29 | 1.9E-7 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115140 | chr20:25285507 | NINL | chr20:25433338-25566153:- | -0.36 | -7.49 | 3.3E-13 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115140 | chr20:25285507 | PYGB | chr20:25228706-25278647:+ | -0.15 | -3.74 | 0.000202 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115146 | chr20:25304507 | ENTPD6 | chr20:25176339-25207360:+ | 0.31 | 6.94 | 1.24E-11 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115146 | chr20:25304507 | FAM182A | chr20:26035250-26067552:+ | 0.18 | 3.4 | 0.000741 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115146 | chr20:25304507 | FAM182B | chr20:25744102-25848786:- | -0.27 | -5.62 | 3.21E-8 | Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs7267979 | 1 | rs6115146 | chr20:25304507 | NINL | chr20:25433338-25566153:- | 0.35 | 7.18 | 2.68E-12 | Liver enzyme levels (alkaline phosphatase) |